Anti-CDKL5抗体- C-terminal (ab71697)

概述

  • 产品名称Anti-CDKL5抗体- C-terminal
    参阅全部 CDKL5 一抗
  • 描述
    兔多克隆抗体to CDKL5 - C-terminal
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide from the C terminal region of human CDKL5 conjugated to KLH.

  • 阳性对照
    • Mouse lung tissue lysate. Human lung carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab71697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 116 kDa (predicted molecular weight: 116 kDa).
IHC-P 1/10 - 1/50.

靶标

  • 功能Mediates phosphorylation of MECP2.
  • 组织特异性Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
  • 疾病相关Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
    Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cdkl5 antibody
    • CDKL5_HUMAN antibody
    • Cyclin dependent kinase 5 transcript antibody
    • Cyclin-dependent kinase-like 5 antibody
    • EIEE2 antibody
    • ISSX antibody
    • Serine/threonine kinase 9 antibody
    • Serine/threonine-protein kinase 9 antibody
    • Stk9 antibody
    see all

Anti-CDKL5 antibody - C-terminal 图像

  • Anti-CDKL5 antibody - C-terminal (ab71697) at 1/100 dilution + mouse lung tissue lysate at 12.5 µg

    Predicted band size : 116 kDa
    Observed band size : 116 kDa
    Additional bands at : 70 kDa. We are unsure as to the identity of these extra bands.
  • ab71697, at 1/10 dilution, staining CDKL5 in human lung carcinoma by Immunohistochemistry using formalin fixed, paraffin embedded tissue. ab71697 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-CDKL5 antibody - C-terminal (ab71697)参考文献

ab71697 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71697.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"