Anti-Cdk9 (phospho T186)抗体(ab79178)

概述

  • 产品名称
    Anti-Cdk9 (phospho T186)抗体
    参阅全部 Cdk9 一抗
  • 描述
    兔多克隆抗体to Cdk9 (phospho T186)
  • 特异性
    ab79178 detects endogenous levels of CDK9 only when phosphorylated at threonine 186.
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Cdk9 around the phosphorylation site of threonine 186 (R-Y-TP-N-R).

  • 阳性对照
    • 3T3 cells

性能

应用

Our Abpromise guarantee covers the use of ab79178 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.
ELISA 1/20000.

靶标

  • 功能
    Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-2K antibody
    • CDC2 related kinase antibody
    • CDC2L4 antibody
    • Cdk 9 antibody
    • Cdk9 antibody
    • CDK9_HUMAN antibody
    • Cell division cycle 2-like protein kinase 4 antibody
    • Cell division protein kinase 9 antibody
    • CTK1 antibody
    • Cyclin dependent kinase 9 antibody
    • Cyclin-dependent kinase 9 antibody
    • PITALRE antibody
    • Serine/threonine-protein kinase PITALRE antibody
    • TAK antibody
    • Tat associated kinase complex catalytic subunit antibody
    see all

图片

  • All lanes : Anti-Cdk9 (phospho T186) antibody (ab79178)

    Lane 1 : 3T3 cells treated with Forskolin (40 nM, 30 minutes)
    Lane 2 : 3T3 cells treated with Forskolin (40 nM, 30 minutes) with phospho peptide


    Predicted band size : 43 kDa
    Observed band size : 43 kDa

实验方案

文献

ab79178 has not yet been referenced specifically in any publications.

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