Anti-CDC42 binding protein kinase alpha抗体(ab96659)

概述

  • 产品名称Anti-CDC42 binding protein kinase alpha抗体
    参阅全部 CDC42 binding protein kinase alpha 一抗
  • 描述
    兔多克隆抗体to CDC42 binding protein kinase alpha
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 373-574 of Human CDC42 binding protein kinase alpha isoform 3 (NP_055641).

  • 阳性对照
    • H1299, A549 and HeLa whole cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab96659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 186 kDa.
IHC-P 1/100 - 1/500. Perform heat-mediated antigen retrieval with 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0)

靶标

  • 功能May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
  • 组织特异性Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 CNH domain.
    Contains 1 CRIB domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A930014J19Rik antibody
    • CDC42 binding protein kinase alpha (DMPK like) antibody
    • CDC42 binding protein kinase alpha antibody
    • CDC42 binding protein kinase alpha dmpk like antibody
    • CDC42 binding protein kinase beta antibody
    • CDC42-binding protein kinase alpha antibody
    • CDC42BPA antibody
    • DKFZp686L1738 antibody
    • DKFZp686P1738 antibody
    • DMPK like antibody
    • DMPK-like alpha antibody
    • FLJ23347 antibody
    • KIAA0451 antibody
    • MGC189823 antibody
    • MRCK alpha antibody
    • mrck antibody
    • mrcka antibody
    • MRCKA_HUMAN antibody
    • Myotonic dystrophy kinase related CDC42 binding protein kinase alpha antibody
    • Myotonic dystrophy kinase-related CDC42-binding kinase alpha antibody
    • Myotonic dystrophy protein kinase-like alpha antibody
    • OTTHUMP00000035727 antibody
    • OTTHUMP00000035728 antibody
    • OTTHUMP00000035729 antibody
    • OTTHUMP00000035730 antibody
    • pk428 antibody
    • RP5-1087E8.4 antibody
    • Ser thr protein kinase PK428 antibody
    • Ser thr protein kinase related to the myotonic dystrophy protein kinase antibody
    • Serine/threonine protein kinase MRCK alpha antibody
    • Serine/threonine-protein kinase MRCK alpha antibody
    see all

Anti-CDC42 binding protein kinase alpha antibody 图像

  • Anti-CDC42 binding protein kinase alpha antibody (ab96659) at 1/1500 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 186 kDa
    7.5% SDS PAGE
  • ab96659 staining CDC42 binding protein kinase alpha in SW480 xenograft at 1/100 dilution by Immunohistochemistry (Formalin/PFA-Fixed Paraffin-embedded sections)

Anti-CDC42 binding protein kinase alpha antibody (ab96659)参考文献

This product has been referenced in:
  • Zhu KC  et al. Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1. Oncol Lett 10:2359-2365 (2015). WB ; Human . Read more (PubMed: 26622852) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab96659.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"