Anti-Cdc25C (phospho T48)抗体(ab62191)

概述

  • 产品名称Anti-Cdc25C (phospho T48)抗体
    参阅全部 Cdc25C 一抗
  • 描述
    兔多克隆抗体to Cdc25C (phospho T48)
  • 特异性ab62191 detects endogenous levels of CDc25C only when phosphorylated at threonine 48.
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthesized phosphopeptide derived from human Cdc25C around the phosphorylation site of threonine 48 (P-R-TP-P-V).

  • 阳性对照
    • Human colon carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab62191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 53 kDa.
IHC-P 1/50 - 1/100.
ELISA 1/5000.

靶标

  • 功能Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
  • 序列相似性Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.
  • 发展阶段Expressed predominantly in G2 phase.
  • 翻译后修饰Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CDC 25 antibody
    • Cdc 25C antibody
    • CDC25 antibody
    • CDC25C antibody
    • Cell division cycle 25 homolog C antibody
    • Cell division cycle 25C antibody
    • Cell division cycle 25C protein antibody
    • Dual specificity phosphatase Cdc25C antibody
    • M phase inducer phosphatase 3 antibody
    • M-phase inducer phosphatase 3 antibody
    • Mitosis inducer CDC25 antibody
    • MPIP3 antibody
    • MPIP3_HUMAN antibody
    • Phosphotyrosine phosphatase antibody
    • PPP1R60 antibody
    • protein phosphatase 1, regulatory subunit 60 antibody
    see all

Anti-Cdc25C (phospho T48) antibody 图像

  • ab62191 at a dilution of 1/50 staining paraffin embedded human colon carcinoma tissue section by immunohistochemistry. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-Cdc25C (phospho T48) antibody (ab62191)参考文献

ab62191 has not yet been referenced specifically in any publications.

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