Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
Belongs to the MPI phosphatase family. Contains 1 rhodanese domain.
Expressed predominantly in G2 phase.
Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
ab62191 at a dilution of 1/50 staining paraffin embedded human colon carcinoma tissue section by immunohistochemistry. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.