概述

  • 产品名称Anti-Cdc23抗体
    参阅全部 Cdc23 一抗
  • 描述
    兔多克隆抗体to Cdc23
  • 特异性ab106496 is predicted not to cross-react with other APC family members. Multiple isoforms of Cdc23 are known to exist.
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 17 amino acid synthetic peptide near the center of Human Cdc23 (UniProt Q9UJX2).

  • 阳性对照
    • K562 cell lysate; K562 cells

性能

应用

Our Abpromise guarantee covers the use of ab106496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: Isoform 1, 69 ; Isoform 3, 56 kDa.
ICC Use a concentration of 5 µg/ml.

靶标

  • 功能Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the APC8/CDC23 family.
    Contains 9 TPR repeats.
  • 翻译后修饰Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANAPC8 antibody
    • Anaphase promoting complex subunit 8 antibody
    • Anaphase-promoting complex subunit 8 antibody
    • Apc 8 antibody
    • APC8 antibody
    • Cdc 23 antibody
    • CDC23 antibody
    • CDC23_HUMAN antibody
    • cell division cycle 23 antibody
    • Cell division cycle 23 homolog antibody
    • Cell division cycle protein 23 antibody
    • Cell division cycle protein 23 homolog antibody
    • Cut23 antibody
    • Cyclosome subunit 8 antibody
    see all

Anti-Cdc23 antibody 图像

  • Lane 1 : Anti-Cdc23 antibody (ab106496) at 1 µg/ml
    Lane 2 : Anti-Cdc23 antibody (ab106496) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : Isoform 1, 69 ; Isoform 3, 56 kDa
  • ab106496, at 5 µg/ml, staining Cdc23 in K562 cells by Immunocytochemistry.

Anti-Cdc23 antibody (ab106496)参考文献

ab106496 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106496.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"