Anti-CD96抗体[NK92.39] (ab81717)

概述

  • 产品名称Anti-CD96抗体[NK92.39]
    参阅全部 CD96 一抗
  • 描述
    小鼠单克隆抗体[NK92.39] to CD96
  • 经测试应用适用于: Blocking, Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human NK92 cells

性能

应用

Our Abpromise guarantee covers the use of ab81717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Blocking
Functional Studies
Flow Cyt
  • 应用说明BL: ab81717 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.
    Flow Cyt: Use at a starting dilution of 1/50. Optimal dilutions will depend on the detection system used.
    FuncS: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
    • 组织特异性Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
    • 疾病相关Defects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
      Defects in CD96 are a cause of C-like syndrome (CLSYN) [MIM:605039]; also called Opitz trigonocephaly-like syndrome. The C-like syndrome seems to be a severe form of the C syndrome. It is controversial whether there is (1) a gradient of spectrum in the C syndrome, from the mild form (C syndrome) to the severe form (C-like syndrome), or (2) genetic heterogeneity among the patients with the C syndrome.
    • 序列相似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 2 Ig-like V-type (immunoglobulin-like) domains.
    • 发展阶段Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD96 antibody
      • CD96 molecule antibody
      • Cell surface antigen CD96 antibody
      • DKFZp667E2122 antibody
      • MGC22596 antibody
      • T cell activated increased late expression protein antibody
      • T cell activation, increased late expression antibody
      • T cell surface protein tactile precursor antibody
      • T cell-activated increased late expression protein antibody
      • T-cell surface protein tactile antibody
      • TACT_HUMAN antibody
      • Tactile antibody
      see all

    Anti-CD96 antibody [NK92.39] (ab81717)参考文献

    ab81717 has not yet been referenced specifically in any publications.

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