Anti-CD84抗体[CD84.1.21] - Low endotoxin, Azide free (ab119116)

概述

  • 产品名称Anti-CD84抗体[CD84.1.21] - Low endotoxin, Azide free
    参阅全部 CD84 一抗
  • 描述
    小鼠单克隆抗体[CD84.1.21] to CD84 - Low endotoxin, Azide free
  • 经测试应用适用于: IP, Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human CD84-transfected 300.19 cell line.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.40
    Constituent: 99% PBS
    Note: Azide-free PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明ab119116 is purified from cell culture supernatant by protein A affinity chromatography. Purity: is 95% (by SDS-PAGE), 0.2 µm filter sterilized.
  • 克隆单克隆
  • 克隆编号CD84.1.21
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab119116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.
  • 组织特异性Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.
  • 序列相似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 发展阶段Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.
  • 结构域ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.
  • 翻译后修饰Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation.
    N-glycosylated.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD_antigen=CD84 antibody
    • CD84 antibody
    • CD84 antigen antibody
    • CD84 molecule antibody
    • CDw84 antibody
    • Cell surface antigen MAX.3 antibody
    • hCD84 antibody
    • Hly9 beta antibody
    • Hly9-beta antibody
    • Leucocyte differentiation antigen CD84 antibody
    • Leukocyte Antigen antibody
    • Leukocyte antigen CD84 antibody
    • Leukocyte differentiation antigen antibody
    • Leukocyte differentiation antigen CD84 antibody
    • LY9B antibody
    • mCD84 antibody
    • Signaling lymphocytic activation molecule 5 antibody
    • SLAF5_HUMAN antibody
    • SLAM family member 5 antibody
    • SLAMF5 antibody
    see all

Anti-CD84 antibody [CD84.1.21] - Low endotoxin, Azide free (ab119116)参考文献

ab119116 has not yet been referenced specifically in any publications.

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This antibody does not have blocking function.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"