Anti-CD8 + HLA Class II抗体[733 + LN3] (Dual color: FITC + PE) (ab1236)

概述

  • 产品名称Anti-CD8 + HLA Class II抗体[733 + LN3] (Dual color: FITC + PE)
  • 描述
    小鼠单克隆抗体[733 + LN3] to CD8 + HLA Class II (Dual color: FITC + PE)
  • 偶联物Dual color: FITC + PE
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 常规说明This product is a mixture of two clones: CD8 = Clone:733, Isotype:IgG1, Label:FITC HLA-DR = Clone:LN3, Isotype:IgG2b, Label:PE This product contains sodium azide, which under acid conditions yields hydrazoic acid, a toxic compound. Azide compounds should be diluted with running water before being discarded to avoid deposits in lead or copper plumbing where explosive conditions may develop.

性能

应用

Our Abpromise guarantee covers the use of ab1236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Counting and identification of CD8+ T lymphocytes in human lysed whole peripheral blood or mononuclear cells separated by density gradient.
    Percentage count of CD8 activated lymphocytes.
    Studies of HIV (Human Immunodeficiency Virus) infection.

    CD8(FITC) / HLA-DR (PE) immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.

    10µl ofCD8(FITC) / HLA-DR (PE) is sufficient for labelling 1x106 cells.
  • 靶标

    • 相关性CD8: This antigen is present on human T suppressor/cytotoxic cell subtypes, that represents 20-36% of normal peripheral blood lymphocytes, and on NK cells subset (CD3-CD8+) and thymocytes. Patients with AIDS exhibit T cells lymphopenia, a loss of CD4+ lymphocytes and a relative increase in the CD8+ subtype and in the CD3+CD4-CD8- subtype. HLA-DR (human Class II histocompatibility antigen): This antigen is present on antigen presenting cells (APC), B cells, monocytes, thymic epithelial cells and macrophages. It is also expressed on activated T cells, but not on granulocytes, platelets or red blood cells. Resting T cells or endothelial cells can be induced to express HLA-DR antigens.
    • 细胞定位Membrane; singlepass type I membrane protein.
    • 数据库链接

    Anti-CD8 + HLA Class II antibody [733 + LN3] (Dual color: FITC + PE) (ab1236)参考文献

    ab1236 has not yet been referenced specifically in any publications.

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