Anti-CD8 alpha抗体[MRC OX-8] (FITC) (ab111919)

概述

  • 产品名称Anti-CD8 alpha抗体[MRC OX-8] (FITC)
    参阅全部 CD8 alpha 一抗
  • 描述
    小鼠单克隆抗体[MRC OX-8] to CD8 alpha (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    High molecular weight rat thymocyte glycoproteins

  • 阳性对照
    • Rat strain Wistar, Buffalo, Brown Norway and Fischer 344 thymus cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.02% Sodium azide
    Constituents: 99% PBS, 0.5% BSA
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab111919 was purified from ascitic fluid via Protein G Chromatography
  • 克隆单克隆
  • 克隆编号MRC OX-8
  • 骨髓瘤P3-NS1/1-Ag4-1
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.5µg for 106 cells. ab91356-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
  • 疾病相关Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻译后修饰All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • alpha polypeptide (p32) antibody
    • CD8 antibody
    • CD8 antigen alpha polypeptide antibody
    • CD8 antigen alpha polypeptide (p32) antibody
    • CD8a antibody
    • CD8A antigen antibody
    • CD8A molecule antibody
    • CD8A_HUMAN antibody
    • Leu2 antibody
    • Leu2 T lymphocyte antigen antibody
    • Ly3 antibody
    • LYT3 antibody
    • MAL antibody
    • OKT8 T cell antigen antibody
    • OTTHUMP00000160760 antibody
    • OTTHUMP00000160764 antibody
    • OTTHUMP00000203528 antibody
    • OTTHUMP00000203721 antibody
    • p32 antibody
    • T cell antigen Leu2 antibody
    • T cell co receptor antibody
    • T-cell surface glycoprotein CD8 alpha chain antibody
    • T-lymphocyte differentiation antigen T8/Leu-2 antibody
    • T8 T cell antigen antibody
    • T8/Leu-2 T-lymphocyte differentiation antigen antibody
    see all

Anti-CD8 alpha antibody [MRC OX-8] (FITC) 图像

  • ab111919 at 0.5 µg/106 cells detecting CD8 alpha in Fischer Rat thymus cells by Flow Cytometry. 95% more of the cells were stained than in the control (FITC Mouse IgG1, k). Cells from Rat strains Wistar, Buffalo and Brown Norway were also positive in this assay.

Anti-CD8 alpha antibody [MRC OX-8] (FITC) (ab111919)参考文献

This product has been referenced in:
  • Johnson P  et al. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J 4:2539-45 (1985). Read more (PubMed: 3932064) »
  • Thomas ML & Green JR Molecular nature of the W3/25 and MRC OX-8 marker antigens for rat T lymphocytes: comparisons with mouse and human antigens. Eur J Immunol 13:855-8 (1983). Read more (PubMed: 6416869) »

See all 6 Publications for this product

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