概述

  • 产品名称Anti-CD8 alpha抗体[Du CD8-1]
    参阅全部 CD8 alpha 一抗
  • 描述
    小鼠单克隆抗体[Du CD8-1] to CD8 alpha
  • 特异性Ab41327 recognises Pekin duck CD8 alpha (CD8a), shown to be expressed by thymocytes, splenocytes, peripheral lymphoid cells and the vast majority of bursal cells. We have data to indicate that this antibody may not cross react with Chicken. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • 经测试应用适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Duck
  • 免疫原

    293T cells expressing Pekin Duck CD8 alpha.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • 克隆单克隆
  • 克隆编号Du CD8-1
  • 骨髓瘤Sp2/0
  • 同种型IgG2b
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab41327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IP
  • 应用说明Flow Cyt: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
    IP: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
    • 疾病相关Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
    • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻译后修饰All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
    • 细胞定位Secreted and Cell membrane.
    • Information by UniProt
    • 别名
      • alpha polypeptide (p32) antibody
      • CD8 antibody
      • CD8 antigen alpha polypeptide antibody
      • CD8 antigen alpha polypeptide (p32) antibody
      • CD8a antibody
      • CD8A antigen antibody
      • CD8A molecule antibody
      • CD8A_HUMAN antibody
      • Leu2 antibody
      • Leu2 T lymphocyte antigen antibody
      • Ly3 antibody
      • LYT3 antibody
      • MAL antibody
      • OKT8 T cell antigen antibody
      • OTTHUMP00000160760 antibody
      • OTTHUMP00000160764 antibody
      • OTTHUMP00000203528 antibody
      • OTTHUMP00000203721 antibody
      • p32 antibody
      • T cell antigen Leu2 antibody
      • T cell co receptor antibody
      • T-cell surface glycoprotein CD8 alpha chain antibody
      • T-lymphocyte differentiation antigen T8/Leu-2 antibody
      • T8 T cell antigen antibody
      • T8/Leu-2 T-lymphocyte differentiation antigen antibody
      see all

    Anti-CD8 alpha antibody [Du CD8-1] (ab41327)参考文献

    This product has been referenced in:
    • Young JA & Jefferies W Towards the conservation of endangered avian species: a recombinant West Nile Virus vaccine results in increased humoral and cellular immune responses in Japanese Quail (Coturnix japonica). PLoS One 8:e67137 (2013). Quail . Read more (PubMed: 23825633) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab41327.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"