Anti-CD8 alpha抗体[53-6.7] (Allophycocyanin/Cy7 ®) (ab25456)


  • 产品名称Anti-CD8 alpha抗体[53-6.7] (Allophycocyanin/Cy7 ®)
    参阅全部 CD8 alpha 一抗
  • 描述
    大鼠单克隆抗体[53-6.7] to CD8 alpha (Allophycocyanin/Cy7 ®)
  • 偶联物Allophycocyanin/Cy7 ®. Ex: 650nm, Em: 774nm
  • 特异性ab25456 recognises a chain of the murine CD8 heterodimer.
  • 经测试应用适用于: Flow Cyt, IHC-Fr, IP, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 常规说明This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.

    This antibody blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.



Our Abpromise guarantee covers the use of ab25456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.2µg for 106 cells.
IHC-Fr Use at an assay dependent concentration.

Acetone fixed.

IP Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.

In vivo and in vitro depletion of CD8α+ cells. Fractionation of CD8α+ T cells.


  • 功能Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
  • 疾病相关Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻译后修饰All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • alpha polypeptide (p32) antibody
    • CD8 antibody
    • CD8 antigen alpha polypeptide antibody
    • CD8 antigen alpha polypeptide (p32) antibody
    • CD8a antibody
    • CD8A antigen antibody
    • CD8A molecule antibody
    • CD8A_HUMAN antibody
    • Leu2 antibody
    • Leu2 T lymphocyte antigen antibody
    • Ly3 antibody
    • LYT3 antibody
    • MAL antibody
    • OKT8 T cell antigen antibody
    • OTTHUMP00000160760 antibody
    • OTTHUMP00000160764 antibody
    • OTTHUMP00000203528 antibody
    • OTTHUMP00000203721 antibody
    • p32 antibody
    • T cell antigen Leu2 antibody
    • T cell co receptor antibody
    • T-cell surface glycoprotein CD8 alpha chain antibody
    • T-lymphocyte differentiation antigen T8/Leu-2 antibody
    • T8 T cell antigen antibody
    • T8/Leu-2 T-lymphocyte differentiation antigen antibody
    see all

Anti-CD8 alpha antibody [53-6.7] (Allophycocyanin/Cy7 ®) (ab25456)参考文献

ab25456 has not yet been referenced specifically in any publications.

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