Anti-CD79b抗体[HM79-11] (Phycoerythrin) (ab23421)

概述

  • 产品名称
    Anti-CD79b抗体[HM79-11] (Phycoerythrin)
    参阅全部 CD79b 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[HM79-11] to CD79b (Phycoerythrin)
  • 偶联物
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性
    ab23421 reacts with murine CD79 beta, which is expressed by B cells as part of the B cell receptor complex (immunoglobulin and the CD79 alpha/beta heterodimer).
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    CD79 alpha/CD79 beta heterodimer purified from WEH1231 B cells

  • 常规说明


    This antibody is a B cell specific marker, valuable for the detection of B cells at all maturation stages.

    Purified IgG conjugated to R. Phycoerythrin (RPE).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • Primary antibody说明
    This antibody is a B cell specific marker, valuable for the detection of B cells at all maturation stages.
  • 克隆
    单克隆
  • 克隆编号
    HM79-11
  • 骨髓瘤
    x63-Ag8.653
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab23421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells.

Use 10µl for 106 cells in 100µl.

靶标

  • 功能
    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • 组织特异性
    B-cells.
  • 疾病相关
    Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • 序列相似性
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻译后修饰
    Phosphorylated on tyrosine upon B-cell activation.
  • 细胞定位
    Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AGM6 antibody
    • B cell antigen receptor complex associated protein beta chain antibody
    • B cell specific glycoprotein B29 antibody
    • B-cell antigen receptor complex-associated protein beta chain antibody
    • B-cell-specific glycoprotein B29 antibody
    • B29 antibody
    • B29/Ig-beta/CD79b antibody
    • CD 79b antibody
    • CD79b antibody
    • CD79b antigen (immunoglobulin associated beta) antibody
    • CD79b antigen antibody
    • CD79b molecule antibody
    • CD79b molecule immunoglobulin associated beta antibody
    • CD79b protein antibody
    • CD79B_HUMAN antibody
    • Ig beta antibody
    • Ig-beta antibody
    • IGB antibody
    • Igbeta antibody
    • Immunoglobulin associated B29 antibody
    • Immunoglobulin associated B29 protein antibody
    • Immunoglobulin associated beta antibody
    • Immunoglobulin associated protein antibody
    • Immunoglobulin-associated B29 protein antibody
    • MGC108607 antibody
    see all

Anti-CD79b antibody [HM79-11] (Phycoerythrin) (ab23421)参考文献

ab23421 has not yet been referenced specifically in any publications.

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