Anti-CD79b抗体[CB3-1] (Phycoerythrin) (ab25578)

概述

  • 产品名称Anti-CD79b抗体[CB3-1] (Phycoerythrin)
    参阅全部 CD79b 一抗
  • 描述
    小鼠单克隆抗体[CB3-1] to CD79b (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性The monoclonal antibody CB3-1 reacts with the beta chain of CD79.
  • 经测试应用适用于: Flow Cyt, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    The details of the immunogen for this antibody are not available.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 16% Sucrose, PBS and stabilising agent.
  • Concentration information loading...
  • 纯度IgG fraction
  • 克隆单克隆
  • 克隆编号CB3-1
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25578 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells.
IHC-Fr Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

靶标

  • 功能Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • 组织特异性B-cells.
  • 疾病相关Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻译后修饰Phosphorylated on tyrosine upon B-cell activation.
  • 细胞定位Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AGM6 antibody
    • B cell antigen receptor complex associated protein beta chain antibody
    • B cell specific glycoprotein B29 antibody
    • B-cell antigen receptor complex-associated protein beta chain antibody
    • B-cell-specific glycoprotein B29 antibody
    • B29 antibody
    • B29/Ig-beta/CD79b antibody
    • CD 79b antibody
    • CD79b antibody
    • CD79b antigen (immunoglobulin associated beta) antibody
    • CD79b antigen antibody
    • CD79b molecule antibody
    • CD79b molecule immunoglobulin associated beta antibody
    • CD79b protein antibody
    • CD79B_HUMAN antibody
    • Ig beta antibody
    • Ig-beta antibody
    • IGB antibody
    • Igbeta antibody
    • Immunoglobulin associated B29 antibody
    • Immunoglobulin associated B29 protein antibody
    • Immunoglobulin associated beta antibody
    • Immunoglobulin associated protein antibody
    • Immunoglobulin-associated B29 protein antibody
    • MGC108607 antibody
    see all

Anti-CD79b antibody [CB3-1] (Phycoerythrin) 图像

Anti-CD79b antibody [CB3-1] (Phycoerythrin) (ab25578)参考文献

ab25578 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Further to correspondence with the source of this antibody I can tell you that ab33295; The concentration of the most recent batch of ab33295 is 0.07mg/ml. Unfortunately we do not know the degree of labelling for ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"