Anti-CD62E抗体[ENA1] (Biotin) (ab36688)

概述

  • 产品名称Anti-CD62E抗体[ENA1] (Biotin)
    参阅全部 CD62E 一抗
  • 描述
    小鼠单克隆抗体[ENA1] to CD62E (Biotin)
  • 偶联物Biotin
  • 特异性This antibody reacts with human endothelial cells activated with TNF, IL1 or endotoxin. It was found to react also with cells transfected with the the E-selectin gene.
  • 经测试应用适用于: IHC-Fr, ICC/IFmore details
  • 种属反应性
    与反应: Human, Chimpanzee, Baboon, Cynomolgus Monkey, Rhesus monkey
  • 免疫原

    Tissue/ cell preparation containing human CD3

  • 阳性对照
    • Endothelial cells or a small fresh skin biopsy after incubation with TNF, IL1 or LPS.
  • 常规说明


    This antibody is useful for the staining of CD62E expressing endothelial cells. This antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.

性能

应用

Our Abpromise guarantee covers the use of ab36688 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.

Fixed with acetone, followed by incubation for 10 min in chloroform.

ICC/IF Use at an assay dependent concentration.

Fixed with paraformaldehyde.

靶标

  • 功能Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
  • 序列相似性Belongs to the selectin/LECAM family.
    Contains 1 C-type lectin domain.
    Contains 1 EGF-like domain.
    Contains 6 Sushi (CCP/SCR) domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD26E antibody
    • CD62 antigen-like family member E antibody
    • CD62E antibody
    • E selectin antibody
    • E-selectin antibody
    • ELAM antibody
    • ELAM-1 antibody
    • ELAM1 antibody
    • Endothelial adhesion molecule 1 antibody
    • Endothelial leukocyte adhesion molecule 1 antibody
    • ESEL antibody
    • LECAM2 antibody
    • Leukocyte-endothelial cell adhesion molecule 2 antibody
    • LYAM2_HUMAN antibody
    • Sele antibody
    • Selectin E antibody
    see all

Anti-CD62E antibody [ENA1] (Biotin) (ab36688)参考文献

This product has been referenced in:
  • Leeuwenberg JF  et al. Adhesion of polymorphonuclear cells to human endothelial cells. Adhesion-molecule-dependent, and Fc receptor-mediated adhesion-molecule-independent mechanisms. Clin Exp Immunol 81:496-500 (1990). Read more (PubMed: 1697800) »
  • Leeuwenberg JF  et al. Functional polymorphism of IgG FcRII (CD32) on human neutrophils. Immunology 71:301-4 (1990). Read more (PubMed: 2146215) »

See all 3 Publications for this product

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