概述

  • 产品名称Anti-CD51 + CD61抗体[23C6]
    参阅全部 CD51 + CD61 一抗
  • 描述
    小鼠单克隆抗体[23C6] to CD51 + CD61
  • 特异性This antibody recognises the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. The antibody reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
  • 经测试应用适用于: Flow Cyt, IP, IHC-Frmore details
    不适用于: IHC-P
  • 种属反应性
    与反应: Chicken, Human
    不与反应: Rabbit, Cow, Pig
  • 免疫原

    Osteoclasts from osteoclastomas

性能

应用

Our Abpromise guarantee covers the use of ab34226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/40 - 1/80. Use 10µl of suggested dilution for 106 cells in 100µl.



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
  • 应用说明Is unsuitable for IHC-P.
  • 靶标

    • 相关性Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.
    • 细胞定位Cell Membrane; single-pass type I membrane protein.
    • 数据库链接
    • 别名
      • Antigen identified by monoclonal antibody L230 antibody
      • CD51 antibody
      • CD51 antigen antibody
      • CD61 antibody
      • CD61 antigen antibody
      • DKFZp686A08142 antibody
      • GP3A antibody
      • GPIIIa antibody
      • Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody
      • Integrin alpha v antibody
      • Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody
      • Integrin beta 3 antibody
      • Integrin beta chain beta 3 antibody
      • ITGAV antibody
      • ITGB3 antibody
      • MSK8 antibody
      • Platelet glycoprotein IIIa antibody
      • Platelet membrane glycoprotein IIIa antibody
      • Vitronectin receptor subunit alpha antibody
      • VNRA antibody
      see all

    Anti-CD51 + CD61 antibody [23C6] (ab34226)参考文献

    This product has been referenced in:
    • Behjati S  et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet 45:1479-82 (2013). Human . Read more (PubMed: 24162739) »

    See 1 Publication for this product

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