Anti-CD45RO抗体[UCHL1] (Biotin) (ab19741)


  • 产品名称Anti-CD45RO抗体[UCHL1] (Biotin)
    参阅全部 CD45RO 一抗
  • 描述
    小鼠单克隆抗体[UCHL1] to CD45RO (Biotin)
  • 偶联物Biotin
  • 特异性Recognizes the low molecular weight (Mr 180kDa) isoform of the leucocyte common antigen (LCA) which is part of a family of protein tryosine phosphatases. The CD45RO antigen is present on most thymocytes, about 40% of resting peripheral blood T-lymphocytes and the majority of T-cells in skin reactive infiltrates and T-cell malignancies. CD45RO is also found on a subset of B-cells and some B-cell lymphomas. NK cells do not express the CD45RO antigen. It is also present on monocytes, macrophages and granulocytes.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    IL-2 dependent T-cell line CA1.

  • 常规说明

    Concentration of the product was found at OD280nm.

    NK cells do not express the CD45RO antigen. It is also present on monocytes, macrophages and granulocytes.

    When activated with phytohemagglutinin (PHA), naive T-cells lose the CD45RA antigen and begin to express the CD45RO antigen. Therefore, Anti-CD45RO may be a marker for memory T-cells. Anti-CD45RO may be used in formalin-fixed and paraffin-embedded tissues as well as frozen sections and cell suspensions.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 1.0% BSA, 0.01M PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Protein G chromatography
  • Primary antibody说明NK cells do not express the CD45RO antigen. It is also present on monocytes, macrophages and granulocytes.
  • 克隆单克隆
  • 克隆编号UCHL1
  • 同种型IgG2a
  • 研究领域


Our Abpromise guarantee covers the use of ab19741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 106 cells. ab97679-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


  • 功能Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
  • 疾病相关Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
    Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 tyrosine-protein phosphatase domains.
  • 结构域The first PTPase domain interacts with SKAP1.
  • 翻译后修饰Heavily N- and O-glycosylated.
  • 细胞定位Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B220 antibody
    • CD45 antibody
    • cd45 antigen antibody
    • CD45R antibody
    • GP180 antibody
    • L-CA antibody
    • lca antibody
    • Leukocyte common antigen antibody
    • LY 5 antibody
    • LY5 antibody
    • Protein tyrosine phosphatase, receptor type, C antibody
    • Protein tyrosine phosphatase, receptor type, c polypeptide antibody
    • Ptprc antibody
    • PTPRC_HUMAN antibody
    • Receptor-type tyrosine-protein phosphatase C antibody
    • T200 antibody
    • T200 glycoprotein antibody
    • T200 leukocyte common antigen antibody
    see all

Anti-CD45RO antibody [UCHL1] (Biotin) (ab19741)参考文献

ab19741 has not yet been referenced specifically in any publications.

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