概述

  • 产品名称
    Anti-CD45RC抗体[IBL-8]
    参阅全部 CD45RC 一抗
  • 描述
    大鼠单克隆抗体[IBL-8] to CD45RC
  • 特异性
    This antibody recognises the exon C-dependent RC isoform of CD45. It reacts strongly with B cells and less intensely with most CD8+ T cells. It does not recognise CD4+ T cells.
  • 经测试应用
    适用于: Flow Cyt, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse spleen cells.

性能

应用

Our Abpromise guarantee covers the use of ab3135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IHC-Fr
IP
  • 应用说明
    Recommended range of antibody concentration is 1 - 10 µg/ml.
    Not tested in applications other than those listed above.

    Optimal dilutions / concentrations should be determined by the end user.
  • 靶标

    • 相关性
      The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
    • 细胞定位
      Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
    • 数据库链接
    • 别名
      • B220 antibody
      • CD45 antibody
      • CD45R antibody
      • EC 3.1.3.48 antibody
      • GP180 antibody
      • L-CA antibody
      • LCA antibody
      • Leukocyte common antigen antibody
      • loc antibody
      • Ly-5 antibody
      • LY5 antibody
      • Ly5, homolog of antibody
      • Lymphocyte antigen 5 antibody
      • Lyt-4 antibody
      • Protein tyrosine phosphatase receptor type C antibody
      • PTPRC antibody
      • Receptor-type tyrosine-protein phosphatase C antibody
      • RT7 antibody
      • T200 antibody
      • T200 Glycoprotein antibody
      see all

    文献

    This product has been referenced in:
    • Zhao HY  et al. Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients. Onco Targets Ther 7:1301-10 (2014). IHC . Read more (PubMed: 25114572) »

    See 1 Publication for this product

    客户评价及客户问答

    Thank you for your inquiry.

    I am sorry for the delay in my answer. I was waiting for an answer from the sources of these antibodies.

    I can confirm that both antibodies were not tested from the lab with other CD45 isoforms.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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