Anti-CD45抗体[Y321] (ab32437)


  • 产品名称Anti-CD45抗体[Y321]
    参阅全部 CD45 一抗
  • 描述
    兔单克隆抗体[Y321] to CD45
  • 经测试应用适用于: WB, IPmore details
    不适用于: Flow Cyt or IHC
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in the leukocyte common antigen domain of human CD45

  • 表位extracellular domain (aa 36-52)
  • 阳性对照
    • Jurkat cell lysate
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab32437 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000 - 1/10000. Detects a band of approximately 180 kDa (predicted molecular weight: 147 kDa).
IP 1/50.
  • 应用说明Is unsuitable for Flow Cyt or IHC.
  • 靶标

    • 功能Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.
    • 疾病相关Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
      Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
    • 序列相似性Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 2 tyrosine-protein phosphatase domains.
    • 结构域The first PTPase domain interacts with SKAP1.
    • 翻译后修饰Heavily N- and O-glycosylated.
    • 细胞定位Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B220 antibody
      • CD 45 antibody
      • CD45 antibody
      • CD45 antigen antibody
      • CD45R antibody
      • GP180 antibody
      • L-CA antibody
      • LCA antibody
      • Leukocyte common antigen antibody
      • loc antibody
      • Ly-5 antibody
      • LY5 antibody
      • Ly5, homolog of antibody
      • Lyt-4 antibody
      • OTTHUMP00000033813 antibody
      • OTTHUMP00000033816 antibody
      • OTTHUMP00000033817 antibody
      • OTTHUMP00000038574 antibody
      • Protein tyrosine phosphatase receptor type c polypeptide antibody
      • protein tyrosine phosphatase, receptor type, C antibody
      • Ptprc antibody
      • PTPRC_HUMAN antibody
      • Receptor-type tyrosine-protein phosphatase C antibody
      • T200 antibody
      • T200 glycoprotein antibody
      • T200 leukocyte common antigen antibody
      see all

    Anti-CD45 antibody [Y321] 图像

    Anti-CD45 antibody [Y321] (ab32437)参考文献

    ab32437 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry.

    I will be pleased to help answer your questions. I am sorry I am not aware if you aer using the antibody in western blot or IP, so I can provide information for both.

    The recommended dilutions of antibo...

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    Thank you for your phone call today.

    The antibody can be used at dilution of 1/50 in Immunoprecipitation.

    The conc. of this antibody is batch specific, we can provide exact conc. if the received batch number is provided.


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