概述

  • 产品名称Anti-CD43抗体[MEM-59]
    参阅全部 CD43 一抗
  • 描述
    小鼠单克隆抗体[MEM-59] to CD43
  • 特异性Recognizes neuraminidase-sensitive epitope on human CD43 molecule (Leukosialin), which is involved in lymphocyte activation.
  • 经测试应用适用于: Flow Cyt, IHC-P, IP, WB, Functional Studiesmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue, cells or virus corresponding to Human CD43.

  • 阳性对照
    • Positive tissue: spleen, thymus, tonsil

性能

应用

Our Abpromise guarantee covers the use of ab9088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use a concentration of 1 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-P Use a concentration of 10 µg/ml.
IP Use at an assay dependent concentration.
WB 1/100. Use under non-reducing conditions.
Functional Studies Use at an assay dependent concentration. The antibody activates T lymphocytes and also induces apoptosis in hemopoietic progenitor cells.

靶标

  • 功能One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.
  • 组织特异性Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
  • 翻译后修饰Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 43 antibody
    • CD43 antibody
    • CD43 antigen antibody
    • Galactoglycoprotein antibody
    • GALGP antibody
    • GPL 115 antibody
    • GPL115 antibody
    • Human gene for sialophorin antibody
    • Leucocyte sialoglycoprotein antibody
    • LEUK_HUMAN antibody
    • Leukocyte large sialoglycoprotein antibody
    • Leukocyte sialoglycoprotein antibody
    • Leukosialin antibody
    • LSN antibody
    • Ly-48 antibody
    • sialophorin (gpL115, leukosialin, CD43) antibody
    • Sialophorin antibody
    • Spn antibody
    see all

Anti-CD43 antibody [MEM-59] (ab9088)参考文献

This product has been referenced in:
  • Cermak L  et al. Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. J Biol Chem 277:7955-61 (2002). Read more (PubMed: 11773067) »
  • Alvarado M  et al. MEM-59 monoclonal antibody detects a CD43 epitope involved in lymphocyte activation. Eur J Immunol 25:1051-5 (1995). Read more (PubMed: 7537669) »

See all 5 Publications for this product

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Thank you for your email. Human T lymphocytes were used as the immunogen to generate ab9088. This antibody recognizes neuraminidase-sensitive epitope on human CD43 molecule (Leukosialin), which is involved in lymphocyte activation. If you have any a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"