PE/Cy7® Anti-CD41抗体[MWReg30] (ab95726)
Key features and details
- PE/Cy7® Rat monoclonal [MWReg30] to CD41
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE/Cy7®. Ex: 496nm, Em: 774nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
PE/Cy7® Anti-CD41抗体[MWReg30]
参阅全部 CD41 一抗 -
描述
PE/Cy7®大鼠单克隆抗体[MWReg30] to CD41 -
宿主
Rat -
偶联物
PE/Cy7®. Ex: 496nm, Em: 774nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse CD41. Mouse platelets
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阳性对照
- Mouse platelets
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.1% Gelatin, PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
MWReg30 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95726于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 0.25-0.5µg for 105-8 cells.
A final volume of 100µl is recommended.
ab154459 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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说明 |
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Flow Cyt
Use 0.25-0.5µg for 105-8 cells. A final volume of 100µl is recommended.
ab154459 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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靶标
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功能
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. -
组织特异性
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. -
疾病相关
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16399 Mouse
- SwissProt: Q9QUM0 Mouse
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别名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
see all
数据表及文件
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Datasheet download
文献 (4)
ab95726 被引用在 4 文献中.
- Bertrand JY et al. Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U S A 102:134-9 (2005). PubMed: 15623562
- Mitjavila-Garcia MT et al. Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development 129:2003-13 (2002). PubMed: 11934866
- Teeling JL et al. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Blood 98:1095-9 (2001). PubMed: 11493456
- Nieswandt B et al. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. Blood 94:684-93 (1999). PubMed: 10397735