Anti-CD41抗体[MWReg30] (ab33661)
Key features and details
- Rat monoclonal [MWReg30] to CD41
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
Anti-CD41抗体[MWReg30]
参阅全部 CD41 一抗 -
描述
大鼠单克隆抗体[MWReg30] to CD41 -
宿主
Rat -
特异性
ab33661 recognizes integrin alpha IIb subunit CD41 -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
The details of the immunogen for this antibody are not available.
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常规说明
The azide free version is ab94960.Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant -
Primary antibody说明
Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo. -
克隆
单克隆 -
克隆编号
MWReg30 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab33661于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt | (1) |
1/50 - 1/100.
Use 10μl of the suggested working dilution to label 106 cells in 100μl. |
说明 |
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Flow Cyt
1/50 - 1/100. Use 10μl of the suggested working dilution to label 106 cells in 100μl. |
靶标
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功能
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. -
组织特异性
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. -
疾病相关
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16399 Mouse
- SwissProt: Q9QUM0 Mouse
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别名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (23)
ab33661 被引用在 23 文献中.
- Arnold S et al. Single and Multiplex Immunohistochemistry to Detect Platelets and Neutrophils in Rat and Porcine Tissues. Methods Protoc 5:N/A (2022). PubMed: 36136817
- Han X et al. Analysis of glucose metabolism by 18F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage. Sci Rep 11:10885 (2021). PubMed: 34035344
- Ren J et al. Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress. Cancer Res 81:2373-2385 (2021). PubMed: 33687949
- Qi Q et al. Platelets induce increased estrogen production through NF-?B and TGF-ß1 signaling pathways in endometriotic stromal cells. Sci Rep 10:1281 (2020). PubMed: 31992765
- Zhang H et al. Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury. Front Immunol 11:987 (2020). PubMed: 32528475