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功能
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
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组织特异性
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
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疾病相关
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
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序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
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细胞定位
Membrane.
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Information by UniProt
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数据库链接
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别名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
- CD41 antibody
- CD41B antibody
- form 2 antibody
- GP2B antibody
- GPalpha IIb antibody
- GPIIb antibody
- GT antibody
- GTA antibody
- HPA3 antibody
- Integrin alpha 2b antibody
- Integrin alpha IIb antibody
- Integrin alpha-IIb light chain antibody
- Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
- ITA2B_HUMAN antibody
- Itga2b antibody
- ITGAB antibody
- platelet fibrinogen receptor, alpha subunit antibody
- platelet glycoprotein IIb of IIb/IIIa complex antibody
- Platelet membrane glycoprotein IIb antibody
- platelet specific antigen BAK antibody
- PPP1R93 antibody
see all