概述
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产品名称Anti-CD41抗体[HIP2]
参阅全部 CD41 一抗 -
描述小鼠单克隆抗体[HIP2] to CD41
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经测试应用适用于: Flow Cyt, IHC-Frmore details
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种属反应性与反应: Human
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免疫原
Full length native protein (purified) corresponding to Human CD41. Full length native protein (purified) (Human).
Database link: P08514
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4 -
Concentration information loading... -
纯度Protein G purified
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克隆单克隆
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克隆编号HIP2
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同种型IgG3
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab15026 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
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| Flow Cyt | Use at an assay dependent concentration. Can be used for the analysis of human platelets at approximately 1 mg/100 ml of blood. ab91537-Mouse monoclonal IgG3, is suitable for use as an isotype control with this antibody. |
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| IHC-Fr | Use at an assay dependent concentration. |
靶标
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功能Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
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组织特异性Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
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疾病相关Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
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序列相似性Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
细胞定位Membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 3674 Human
- Omim: 607759 Human
- SwissProt: P08514 Human
- Unigene: 411312 Human
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别名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
see all
Anti-CD41 antibody [HIP2] (ab15026)参考文献
ab15026 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"