Anti-CD40L抗体[MR-1] - Low endotoxin, Azide free (ab99895)

概述

  • 产品名称Anti-CD40L抗体[MR-1] - Low endotoxin, Azide free
    参阅全部 CD40L 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[MR-1] to CD40L - Low endotoxin, Azide free
  • 经测试应用适用于: IP, IHC-P, ICC, Flow Cyt, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Activated Mouse Th1 clone D1.6.

  • 阳性对照
    • 6-8 hour activated mouse splenocytes
  • 常规说明low endotoxin

性能

应用

Our Abpromise guarantee covers the use of ab99895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution.
IHC-P Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
Flow Cyt Use a concentration of 4 µg/ml.
Functional Studies Use at an assay dependent dilution. Blocking T cell costimulation in vivo.

靶标

  • 功能Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
    Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
  • 组织特异性Specifically expressed on activated CD4+ T-lymphocytes.
  • 疾病相关Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
    N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
    Not O-glycosylated.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 40L antibody
    • CD154 antibody
    • CD40 antigen ligand antibody
    • CD40 ligand antibody
    • CD40 ligand, soluble form antibody
    • CD40-L antibody
    • CD40L antibody
    • CD40L_HUMAN antibody
    • CD40LG antibody
    • gp39 antibody
    • hCD40L antibody
    • HIGM1 antibody
    • IGM antibody
    • IMD3 antibody
    • T B cell activating molecule antibody
    • T BAM antibody
    • T-cell antigen Gp39 antibody
    • TNF-related activation protein antibody
    • TNFSF5 antibody
    • TrAP antibody
    • Tumor necrosis factor (ligand) superfamily member 5 antibody
    • Tumor necrosis factor ligand superfamily member 5 antibody
    see all

Anti-CD40L antibody [MR-1] - Low endotoxin, Azide free (ab99895)参考文献

This product has been referenced in:
  • Hwang Y  et al. Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L. Infect Immun 68:511-7 (2000). Read more (PubMed: 10639411) »
  • Lode HN  et al. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105:1623-30 (2000). Read more (PubMed: 10841521) »

See all 5 Publications for this product

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