Anti-CD40L抗体[MR-1] (ab99894)

概述

  • 产品名称
    Anti-CD40L抗体[MR-1]
    参阅全部 CD40L 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[MR-1] to CD40L
  • 特异性
    This antibody detects mouse CD154 / CD40L (CD40 ligand), a 39 kDa cell surface glycoprotein expressed predominantly on activated CD4+ lymphocytes.
  • 经测试应用
    适用于: IHC-P, IHC-Fr, IP, Functional Studies, ICC, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue/ cell preparation - activated mouse Th1 clone D1.6

  • 阳性对照
    • 6-8 hour activated mouse splenocytes
  • 常规说明


    Functional Application: Blocking T cell costimulation in vivo.

性能

应用

Our Abpromise guarantee covers the use of ab99894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
Functional Studies Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
Flow Cyt Use a concentration of 4 µg/ml.

靶标

  • 功能
    Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
    Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
  • 组织特异性
    Specifically expressed on activated CD4+ T-lymphocytes.
  • 疾病相关
    Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
  • 序列相似性
    Belongs to the tumor necrosis factor family.
  • 翻译后修饰
    The soluble form derives from the membrane form by proteolytic processing.
    N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
    Not O-glycosylated.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 40L antibody
    • CD154 antibody
    • CD40 antigen ligand antibody
    • CD40 ligand antibody
    • CD40 ligand, soluble form antibody
    • CD40-L antibody
    • CD40L antibody
    • CD40L_HUMAN antibody
    • CD40LG antibody
    • gp39 antibody
    • hCD40L antibody
    • HIGM1 antibody
    • IGM antibody
    • IMD3 antibody
    • T B cell activating molecule antibody
    • T BAM antibody
    • T-cell antigen Gp39 antibody
    • TNF-related activation protein antibody
    • TNFSF5 antibody
    • TrAP antibody
    • Tumor necrosis factor (ligand) superfamily member 5 antibody
    • Tumor necrosis factor ligand superfamily member 5 antibody
    see all

文献

ab99894 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for contacting Abcam regarding our CD40 and CD40L antibodies. Below please find the requested information: ab2391 Rabbit Polyclonal to CD40L - Unfortunately the specific immunogen sequence is proprietary, however I can inform you that...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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