PE/Cy5® Anti-CD40抗体[1C10] (ab25044)
Key features and details
- PE/Cy5® Rat monoclonal [1C10] to CD40
- Suitable for: IP, Flow Cyt, Functional Studies
- Reacts with: Mouse
- Conjugation: PE/Cy5®. Ex: 496nm, Em: 670nm
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
PE/Cy5® Anti-CD40抗体[1C10]
参阅全部 CD40 一抗 -
描述
PE/Cy5®大鼠单克隆抗体[1C10] to CD40 -
宿主
Rat -
偶联物
PE/Cy5®. Ex: 496nm, Em: 670nm -
经测试应用
适用于: IP, Flow Cyt, Functional Studiesmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant fragment corresponding to CD40. sCD40
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常规说明
This antibody closely resembles the gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.
This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.1
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.2% Gelatin, 16% Sucrose
Stabilising agent. -
Concentration information loading...
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纯度
Affinity purified -
Primary antibody说明
This antibody closely resembles the gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors. -
克隆
单克隆 -
克隆编号
1C10 -
同种型
IgG2a -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25044于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IP |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
|
|
Functional Studies |
Use at an assay dependent concentration.
In vitro induction of proliferation of mature B lymphocytes. |
说明 |
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IP
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. In vitro induction of proliferation of mature B lymphocytes. |
靶标
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功能
Receptor for TNFSF5/CD40LG. -
组织特异性
B-cells and in primary carcinomas. -
疾病相关
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. -
序列相似性
Contains 4 TNFR-Cys repeats. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 21939 Mouse
- SwissProt: P27512 Mouse
- Unigene: 271833 Mouse
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别名
- AI326936 antibody
- B cell associated molecule CD40 antibody
- B cell surface antigen CD40 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab25044 被引用在 1 文献中.
- Melo-Baez B et al. MicroRNAs from Extracellular Vesicles Secreted by Bovine Embryos as Early Biomarkers of Developmental Competence. Int J Mol Sci 21:N/A (2020). PubMed: 33255183