Anti-CD4抗体[RPA-T4] (Biotin) (ab34271)

概述

  • 产品名称Anti-CD4抗体[RPA-T4] (Biotin)
    参阅全部 CD4 一抗
  • 描述
    小鼠单克隆抗体[RPA-T4] to CD4 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation (Human) -PHA blasts.

  • 表位this antibody recognises an epitope within domain 1, of the extracellular region, of the CD4 molecule.
  • 阳性对照
    • human peripheral blood lymphocytes
  • 常规说明


    This antibody has been reported to block gp120-CD4 interaction and inhibit syncytium formation.

性能

应用

Our Abpromise guarantee covers the use of ab34271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells.

Use neat - 1/10. Use 10µl of this dilution for 106 cells or 100µl whole blood.





ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
  • 序列相似性Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻译后修饰Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • 细胞定位Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 4 antibody
    • CD4 (L3T4) antibody
    • CD4 antibody
    • CD4 antigen (p55) antibody
    • CD4 antigen antibody
    • CD4 molecule antibody
    • CD4 receptor antibody
    • CD4+ Lymphocyte deficiency, included antibody
    • CD4_HUMAN antibody
    • CD4mut antibody
    • L3T4 antibody
    • Leu3 antibody
    • Ly-4 antibody
    • Lymphocyte antigen CD4 antibody
    • MGC165891 antibody
    • OTTHUMP00000238897 antibody
    • p55 antibody
    • T cell antigen T4 antibody
    • T cell antigen T4/LEU3 antibody
    • T cell differentiation antigen L3T4 antibody
    • T cell OKT4 deficiency, included antibody
    • T cell surface antigen T4/Leu 3 antibody
    • T cell surface antigen T4/Leu3 antibody
    • T cell surface glycoprotein CD4 antibody
    • T-cell surface antigen T4/Leu-3 antibody
    • T-cell surface glycoprotein CD4 antibody
    • W3/25 antibody
    • W3/25 antigen antibody
    see all

Anti-CD4 antibody [RPA-T4] (Biotin) 图像

  • FACS analysis of CD4 expressing cells in human peripheral blood lymphocytes using ab34271.

Anti-CD4 antibody [RPA-T4] (Biotin) (ab34271)参考文献

ab34271 has not yet been referenced specifically in any publications.

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