Anti-CD4抗体[GK1.5] (Phycoerythrin -Texas Red®) (ab51467)

概述

  • 产品名称Anti-CD4抗体[GK1.5] (Phycoerythrin -Texas Red®)
    参阅全部 CD4 一抗
  • 描述
    大鼠单克隆抗体[GK1.5] to CD4 (Phycoerythrin -Texas Red®)
  • 偶联物Phycoerythrin -Texas Red®. Ex: 496nm, Em: 613nm
  • 特异性ab51467 is specific to CD4.
  • 经测试应用适用于: IHC-Fr, IP, Inhibition Assay, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Cloned mouse CTL line V41

性能

应用

Our Abpromise guarantee covers the use of ab51467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration. Inhibition of T helper function.
Fractionation of CD4+ cells: Use at an assay dependent dilution.
In vivo and in vitro depletion of CD4+ cells: Use at an assay dependent dilution.
Flow Cyt Use 0.2µg for 106 cells. ab98984-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
  • 序列相似性Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻译后修饰Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • 细胞定位Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 4 antibody
    • CD4 (L3T4) antibody
    • CD4 antibody
    • CD4 antigen (p55) antibody
    • CD4 antigen antibody
    • CD4 molecule antibody
    • CD4 receptor antibody
    • CD4+ Lymphocyte deficiency, included antibody
    • CD4_HUMAN antibody
    • CD4mut antibody
    • L3T4 antibody
    • Leu3 antibody
    • Ly-4 antibody
    • Lymphocyte antigen CD4 antibody
    • MGC165891 antibody
    • OTTHUMP00000238897 antibody
    • p55 antibody
    • T cell antigen T4 antibody
    • T cell antigen T4/LEU3 antibody
    • T cell differentiation antigen L3T4 antibody
    • T cell OKT4 deficiency, included antibody
    • T cell surface antigen T4/Leu 3 antibody
    • T cell surface antigen T4/Leu3 antibody
    • T cell surface glycoprotein CD4 antibody
    • T-cell surface antigen T4/Leu-3 antibody
    • T-cell surface glycoprotein CD4 antibody
    • W3/25 antibody
    • W3/25 antigen antibody
    see all

Anti-CD4 antibody [GK1.5] (Phycoerythrin -Texas Red®) 图像

  • Flow cytometry analysis of C57BL/6 mouse splenocytes stained with ab51467 and rat anti-mouse CD8α-PE.

Anti-CD4 antibody [GK1.5] (Phycoerythrin -Texas Red®) (ab51467)参考文献

This product has been referenced in:
  • Elgbratt K  et al. A quantitative study of the mechanisms behind thymic atrophy in Gai2-deficient mice during colitis development. PLoS One 7:e36726 (2012). Flow Cyt ; Mouse . Read more (PubMed: 22590596) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"