Tissue/ cell preparation (Mouse) - cloned mouse CTL line V4.
This antibody blocks helper T cell responses to MHC class II antigens,including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. It is important to note that this product is reported to be light sensitive.
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.