存放说明 Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. It is important to note that this product is reported to be light sensitive.
存储溶液 pH: 7.20 Preservative: 0.09% Sodium azide Constituents: 0.142% Dibasic monohydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin
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纯度 Affinity purified
Primary antibody说明 This antibody blocks helper T cell responses to MHC class II antigens,including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
功能 Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
序列相似性 Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
翻译后修饰 Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
细胞定位 Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Information by UniProt
CD 4 antibody
CD4 (L3T4) antibody
Anti-CD4 antibody [GK1.5] (Allophycocyanin) (ab25497)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"