产品名称 Anti-CD4抗体[CA13.1E4] 参阅全部 CD4 一抗
小鼠单克隆抗体[CA13.1E4] to CD4
特异性 ab34071 recognises canine homologue of CD4, a 60kD glycoprotein expressed by T lymphocytes and neutrophils.
IP, IHC-Fr, Flow Cyt more details
Tissue/ cell preparation (Canine Thymocytes)
存放说明 Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液 Preservative: 0.09% Sodium Azide
Constituents: Tissue culture supernatant
纯度 Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明 FACS: Use 25µl for 10 6 cells or 100ul whole blood.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能 Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
序列相似性 Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
翻译后修饰 Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
细胞定位 Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Information by UniProt
CD 4 antibody
CD4 (L3T4) antibody
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"