概述

  • 产品名称Anti-CD3D抗体
    参阅全部 CD3D 一抗
  • 描述
    兔多克隆抗体to CD3D
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Full length protein corresponding to Human CD3D aa 1-171.
    Sequence:

    MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGT LLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELD PATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQ PLRDRDDAQYSHLGGNWARNK


    Database link: P04234

  • 阳性对照
    • Mouse kidney tissue lysate, CD3D transfected 293T cell line lysate, HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab103573 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 19 kDa.
ICC/IF 1/1200.

靶标

  • 功能The CD3 complex mediates signal transduction.
  • 疾病相关Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
  • 序列相似性Contains 1 ITAM domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 形式.
  • 别名
    • CD3d antibody
    • CD3D_HUMAN antibody
    • T-cell receptor T3 delta chain antibody
    • T-cell surface glycoprotein CD3 delta chain antibody

Anti-CD3D antibody 图像

  • Anti-CD3D antibody (ab103573) at 1/500 dilution + Mouse Kidney tissue lysate at 50 µg

    Predicted band size : 19 kDa
  • All lanes : Anti-CD3D antibody (ab103573) at 1/500 dilution

    Lane 1 : CD20 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 19 kDa
  • Proximity Ligation Analysis (PLA) of protein-protein interactions between CD3D and CANX.
    ab103573 at 1/1200 staining CDED in HeLa cells with anti-CANX mouse monoclonal antibody 1/50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.

Anti-CD3D antibody (ab103573)参考文献

ab103573 has not yet been referenced specifically in any publications.

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