概述

  • 产品名称Anti-CD35抗体[E11]
    参阅全部 CD35 一抗
  • 描述
    小鼠单克隆抗体[E11] to CD35
  • 特异性ab76520 is specific for a site in CD35 that is distal from the C3b-binding site, so that it is unable to block CD35 activity. This antibody is highly specific to CD35 and shows no cross-reaction with CD21.
  • 经测试应用适用于: IHC-P, Flow Cyt, ICC/IFmore details
  • 种属反应性
    与反应: Human, Baboon, Rhesus monkey
  • 免疫原

    Intact human monocytes.

  • 表位Distal from the C3b-binding site.
  • 阳性对照
    • Tonsil.

性能

应用

Our Abpromise guarantee covers the use of ab76520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
Flow Cyt
ICC/IF
  • 应用说明Flow Cyt: Use at an assay dependent dilution.
    ICC/IF: Use at an assay dependent dilution.
    IHC-P: 1/50 - 1/100 for 20 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min, and use of a high-sensitivity detection system.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Mediates cellular binding of particles and immune complexes that have activated complement.
    • 组织特异性Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
    • 序列相似性Belongs to the receptors of complement activation (RCA) family.
      Contains 30 Sushi (CCP/SCR) domains.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C3 binding protein antibody
      • C3b/C4b receptor antibody
      • C3BR antibody
      • C4BR antibody
      • CD 35 antibody
      • CD35 antibody
      • CD35 antigen antibody
      • complement component (3b/4b) receptor 1 (Knops blood group) antibody
      • complement component (3b/4b) receptor 1 including Knops blood group system antibody
      • Complement component receptor 1 antibody
      • Complement receptor 1 antibody
      • Complement receptor type 1 antibody
      • CR 1 antibody
      • CR1 antibody
      • CR1_HUMAN antibody
      • KN antibody
      • Knops blood group antigen antibody
      see all

    Anti-CD35 antibody [E11] (ab76520)参考文献

    This product has been referenced in:
    • Hogg N  et al. Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur J Immunol 14:236-43 (1984). Read more (PubMed: 6368248) »
    • Linch DC  et al. Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML. Blood 63:566-73 (1984). Read more (PubMed: 6365201) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"