Anti-CD3 epsilon抗体[145-2C11] (PE/Cy5®) (ab25453)

概述

  • 产品名称Anti-CD3 epsilon抗体[145-2C11] (PE/Cy5®)
    参阅全部 CD3 epsilon 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[145-2C11] to CD3 epsilon (PE/Cy5®)
  • 偶联物PE/Cy5®. Ex: 496nm, Em: 670nm
  • 经测试应用适用于: Functional Studies, Flow Cyt, WB, IP, Celluar Activationmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    H-2Kb specific mouse cytotoxic T lymphocyte clone BM10-37.

  • 表位The 145-2C11 monoclonal antibody recognizes an epitope on the 25kD e chain of the CD3/TCR complex.
  • 常规说明This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.


    In the presence of Fc receptor-bearing accessory cells, soluble ab25453 can activate primed and naïve T cell in vitro. ab25453 can also induce redirected lysis ofspecific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized ab25453 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by ab25453 may result in apoptotic cell death.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 16% Sucrose, 0.2% Gelatin, PBS; Stabilizing agent
  • Concentration information loading...
  • 纯度IgG fraction
  • Primary antibody说明In the presence of Fc receptor-bearing accessory cells, soluble ab25453 can activate primed and naïve T cell in vitro. ab25453 can also induce redirected lysis ofspecific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized ab25453 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by ab25453 may result in apoptotic cell death.
  • 克隆单克隆
  • 克隆编号145-2C11
  • 同种型IgG
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies Use at an assay dependent concentration.

In vitro depletion of CD3+ cells.

Flow Cyt Use 1µg for 106 cells. Ab157805-Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.

ab157805-Armenian Hamster polyclonal IgG, is suitable for use as an isotype control with this antibody.
WB Use at an assay dependent concentration. Predicted molecular weight: 23 kDa.
IP Use at an assay dependent concentration.
Celluar Activation Use at an assay dependent concentration.

T cells.

靶标

  • 功能The CD3 complex mediates signal transduction.
  • 序列相似性Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD3 epsilon antibody
    • CD3e antibody
    • CD3e antigen epsilon polypeptide (TiT3 complex) antibody
    • CD3E antigen epsilon polypeptide antibody
    • CD3E antigen, epsilon subunit antibody
    • CD3e molecule epsilon antibody
    • CD3e molecule, epsilon (CD3 TCR complex) antibody
    • CD3e molecule, epsilon (CD3-TCR complex) antibody
    • CD3E_HUMAN antibody
    • IMD18 antibody
    • T cell antigen receptor complex epsilon subunit of T3 antibody
    • T cell surface antigen T3/Leu 4 epsilon chain antibody
    • T cell surface glycoprotein CD3 epsilon chain antibody
    • T-cell surface antigen T3/Leu-4 epsilon chain antibody
    • T-cell surface glycoprotein CD3 epsilon chain antibody
    • T3E antibody
    • TCRE antibody
    see all

Anti-CD3 epsilon antibody [145-2C11] (PE/Cy5®) (ab25453)参考文献

ab25453 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"