Anti-CD252抗体[RM134L] (Phycoerythrin) (ab95656)

概述

  • 产品名称Anti-CD252抗体[RM134L] (Phycoerythrin)
    参阅全部 CD252 一抗
  • 描述
    大鼠单克隆抗体[RM134L] to CD252 (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse CD252 protein

  • 阳性对照
    • Anti-Mouse IgM and Anti-Mouse CD40 stimulated Mouse BALB/c splenocytes
  • 常规说明


    The RM134L monoclonal antibody inhibits the costimulatory activity of Mouse CD252 transfected cells for anti-CD3-stimulated T cell proliferation.

性能

应用

Our Abpromise guarantee covers the use of ab95656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.25-0.5µg for 105-8 cells. Staining the cell sample in a final volume of 100 µl is recommended.

靶标

  • 功能Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
  • 疾病相关Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 134L antibody
    • CD 252 antibody
    • CD134 antibody
    • CD134 ligand antibody
    • CD134L antibody
    • CD252 antibody
    • CD252 antigen antibody
    • glycoprotein 34 kd antibody
    • Glycoprotein Gp34 antibody
    • GP34 antibody
    • OX-40L antibody
    • OX40 antigen ligand antibody
    • OX40 ligand antibody
    • OX40L antibody
    • TAX transcriptionally-activated glycoprotein 1 antibody
    • TNFL4_HUMAN antibody
    • Tnfsf4 antibody
    • Tumor necrosis factor (ligand) superfamily member 4 antibody
    • Tumor necrosis factor ligand superfamily member 4 antibody
    • TXGP1 antibody
    see all

Anti-CD252 antibody [RM134L] (Phycoerythrin) 图像

  • Flow cytometry staining of 3-day unstimulated (left) and 3-day Anti-Mouse IgM and Anti-Mouse CD40 stimulated (right) BALB/c splenocytes with 0.25 µg of Rat IgG2b ? Isotype Control PE (open histogram) or 0.25 µg of ab95656 (filled histogram). Total viable cells were used for analysis.

Anti-CD252 antibody [RM134L] (Phycoerythrin) (ab95656)参考文献

This product has been referenced in:
  • Tsukada N  et al. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood 95:2434-9 (2000). Read more (PubMed: 10733518) »
  • Akiba H  et al. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 191:375-80 (2000). Read more (PubMed: 10637281) »

See all 3 Publications for this product

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