Anti-CD24抗体[30-F1] (FITC) (ab25673)

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概述

  • 产品名称
    Anti-CD24抗体[30-F1] (FITC)
    参阅全部 CD24 一抗
  • 描述
    大鼠单克隆抗体[30-F1] to CD24 (FITC)
  • 偶联物
    FITC. Ex: 493nm, Em: 528nm
  • 经测试应用
    适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    The details of the immunogen for this antibody are not available.

应用

Our Abpromise guarantee covers the use of ab25673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IP
  • 应用说明
    Flow Cyt: Use 2µg for 106 cells.
    IP: Use at an assay dependent dilution.
    Cell sorting: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • 靶标

    • 功能
      Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
    • 组织特异性
      B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
    • 疾病相关
      Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.
    • 序列相似性
      Belongs to the CD24 family.
    • 翻译后修饰
      Extensively O-glycosylated.
    • 细胞定位
      Cell membrane.
    • Information by UniProt
    • 数据库链接
      • 别名
        • CD 24 antibody
        • CD24 antibody
        • CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
        • CD24 antigen antibody
        • CD24 molecule antibody
        • CD24_HUMAN antibody
        • CD24A antibody
        • FLJ22950 antibody
        • FLJ43543 antibody
        • GPI linked surface mucin antibody
        • Heat stable antigen antibody
        • HSA antibody
        • MGC75043 antibody
        • Nectadrin antibody
        • Signal transducer CD24 antibody
        • Small cell lung carcinoma cluster 4 antigen antibody
        see all

      Anti-CD24 antibody [30-F1] (FITC) (ab25673)参考文献

      ab25673 has not yet been referenced specifically in any publications.

      发表研究结果有使用 ab25673？请让我们知道，以便我们可以引用本数据表中的参考文章。

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