概述
- 产品名称Anti-CD24抗体[30-F1] (FITC)
参阅全部 CD24 一抗 - 描述大鼠单克隆抗体[30-F1] to CD24 (FITC)
- 偶联物FITC. Ex: 493nm, Em: 528nm
- 经测试应用适用于: Flow Cyt, IPmore details
- 种属反应性与反应: Mouse
- 免疫原
The details of the immunogen for this antibody are not available.
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Store at +4°C.
- 存储溶液Preservative: 0.1% Sodium Azide
Constituents: PBS -
Concentration information loading... - 纯度IgG fraction
- 克隆单克隆
- 克隆编号30-F1
- 同种型IgG2c
- 轻链类型kappa
- 研究领域
相关产品
- Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab25673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | ||
| IP |
IP: Use at an assay dependent dilution.
Cell sorting: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
- 功能Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
- 组织特异性B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
- 疾病相关Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.
- 序列相似性Belongs to the CD24 family.
- 翻译后修饰Extensively O-glycosylated.
- 细胞定位Cell membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 12484 Mouse
- SwissProt: P24807 Mouse
- Unigene: 29742 Mouse
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别名
- CD 24 antibody
- CD24 antibody
- CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
see all
Anti-CD24 antibody [30-F1] (FITC) (ab25673)参考文献
ab25673 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"