概述

  • 产品名称
    Anti-CD226抗体[DX11]
    参阅全部 CD226 一抗
  • 描述
    小鼠单克隆抗体[DX11] to CD226
  • 经测试应用
    适用于: Flow Cyt, Functional Studies, IP, Blockingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation (Human) - cytotoxic T lymphocyte clone.

  • 常规说明


    This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
  • Primary antibody说明
    This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.
  • 克隆
    单克隆
  • 克隆编号
    DX11
  • 骨髓瘤
    Sp2/0
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab33397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration. PubMed: 23980210

靶标

  • 功能
    Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
  • 组织特异性
    Expressed by peripheral blood T-lymphocytes.
  • 序列相似性
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • adhesion glycoprotein antibody
    • CD226 antibody
    • CD226 antigen antibody
    • CD226 molecule antibody
    • CD226_HUMAN antibody
    • DNAM 1 antibody
    • DNAM-1 antibody
    • DNAM1 antibody
    • DNAX accessory molecule 1 antibody
    • platelet and T cell activation antigen 1 antibody
    • PTA1 antibody
    • T lineage specific activation antigen 1 antigen antibody
    • TLiSA1 antibody
    see all

图片

  • Human peripheral blood lymphocytes stained with ab33397, using 10µl of the working dilution for 106 cells in 100µl.

文献

This product has been referenced in:
  • Lozano E  et al. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol 191:3673-80 (2013). Blocking ; Human . Read more (PubMed: 23980210) »
  • Lozano E  et al. The TIGIT/CD226 axis regulates human T cell function. J Immunol 188:3869-75 (2012). Read more (PubMed: 22427644) »

See all 3 Publications for this product

客户评价及客户问答

A description of the production and characterization of the CD226 antibody, clone DX11, and the statement regarding inhibition and blocking, are in the following reference.


Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule invol...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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