The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明IHC-P: Use neat for 30-60 minutes at room temperature.
IHC-Fr (acetone-fixed): Use neat for 30-60 minutes at room temperature.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能This protein may be involved in the regulation of B-cell activation and proliferation.
组织特异性Expressed on B-cells.
疾病相关Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
序列相似性Belongs to the MS4A family.
翻译后修饰Phosphorylated. Might be functionally regulated by protein kinase(s).
Groot Kormelink T et al. Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis. PLoS One6:e25392 (2011).
Read more (PubMed: 21980441) »
Kormelink TG et al. Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20) treatment correlates with decrease in disease activity. Ann Rheum Dis69:2137-44 (2010).
Read more (PubMed: 20679475) »