The details of the immunogen for this antibody are not available.
常规说明This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明CellAct (in vitro): Use at an assay dependent dilution.
Flow Cyt: Use 10 µl for 106 cells.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能This protein may be involved in the regulation of B-cell activation and proliferation.
组织特异性Expressed on B-cells.
疾病相关Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
序列相似性Belongs to the MS4A family.
翻译后修饰Phosphorylated. Might be functionally regulated by protein kinase(s).