概述

  • 产品名称Anti-CD20抗体[2H7] (PerCP)
    参阅全部 CD20 一抗
  • 描述
    小鼠单克隆抗体[2H7] to CD20 (PerCP)
  • 偶联物PerCP. Ex: 482nm, Em: 675nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human, Non Human Primates
  • 免疫原

    Human tonsillar B cells.

  • 阳性对照
    • Human blood cells
  • 常规说明

    The mouse monoclonal antibody 2H7 recognizes CD20 (B1, Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on pre-B lymphocytes, resting and activated B cells (not plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

     

    Purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.

性能

应用

Our Abpromise guarantee covers the use of ab114860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells. (or 100 µl of whole blood).



ab172890-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

靶标

  • 功能This protein may be involved in the regulation of B-cell activation and proliferation.
  • 组织特异性Expressed on B-cells.
  • 疾病相关Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性Belongs to the MS4A family.
  • 翻译后修饰Phosphorylated. Might be functionally regulated by protein kinase(s).
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APY antibody
    • ATOPY antibody
    • B lymphocyte antigen CD20 antibody
    • B Lymphocyte Cell Surface Antigen B1 antibody
    • B-lymphocyte antigen CD20 antibody
    • B-lymphocyte cell-surface antigen B1 antibody
    • B-lymphocyte surface antigen B1 antibody
    • B1 antibody
    • Bp 35 antibody
    • Bp35 antibody
    • CD 20 antibody
    • CD20 antibody
    • CD20 antigen antibody
    • CD20 receptor antibody
    • CD20_HUMAN antibody
    • CVID5 antibody
    • Fc epsilon receptor I beta chain antibody
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody
    • FCER1B antibody
    • High affinity immunoglobulin epsilon receptor subunit beta antibody
    • IgE Fc receptor subunit beta antibody
    • IGEL antibody
    • IGER antibody
    • IGHER antibody
    • LEU 16 antibody
    • LEU16 antibody
    • leukocyte surface antigen Leu 16 antibody
    • Leukocyte surface antigen Leu-16 antibody
    • Ly44 antibody
    • Membrane spanning 4 domains A1 antibody
    • Membrane spanning 4 domains subfamily A member 2 antibody
    • Membrane-spanning 4-domains subfamily A member 1 antibody
    • MS4A1 antibody
    • MS4A2 antibody
    • S7 antibody
    see all

Anti-CD20 antibody [2H7] (PerCP) (ab114860)参考文献

This product has been referenced in:
  • Deans JP  et al. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem 273:344-8 (1998). Read more (PubMed: 9417086) »
  • Deans JP  et al. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem 273:344-8 (1998). Read more (PubMed: 9417086) »

See all 4 Publications for this product

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