Anti-CD20抗体[2H7] (ab111274)

概述

  • 产品名称Anti-CD20抗体[2H7]
    参阅全部 CD20 一抗
  • 描述
    小鼠单克隆抗体[2H7] to CD20
  • 经测试应用适用于: IP, IHC-Fr, Flow Cytmore details
  • 种属反应性
    与反应: Human, Non Human Primates
  • 免疫原

    Human tonsillar B cells

  • 表位The epitope recognised by this antibody has been mapped to the following sequence which is found in the large extracellular loop of human CD20: YNCEPANPSEKNSPST

性能

应用

Our Abpromise guarantee covers the use of ab111274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use a concentration of 0.6 µg/ml. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

靶标

  • 功能This protein may be involved in the regulation of B-cell activation and proliferation.
  • 组织特异性Expressed on B-cells.
  • 疾病相关Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性Belongs to the MS4A family.
  • 翻译后修饰Phosphorylated. Might be functionally regulated by protein kinase(s).
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APY antibody
    • ATOPY antibody
    • B lymphocyte antigen CD20 antibody
    • B Lymphocyte Cell Surface Antigen B1 antibody
    • B-lymphocyte antigen CD20 antibody
    • B-lymphocyte cell-surface antigen B1 antibody
    • B-lymphocyte surface antigen B1 antibody
    • B1 antibody
    • Bp 35 antibody
    • Bp35 antibody
    • CD 20 antibody
    • CD20 antibody
    • CD20 antigen antibody
    • CD20 receptor antibody
    • CD20_HUMAN antibody
    • CVID5 antibody
    • Fc epsilon receptor I beta chain antibody
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody
    • FCER1B antibody
    • High affinity immunoglobulin epsilon receptor subunit beta antibody
    • IgE Fc receptor subunit beta antibody
    • IGEL antibody
    • IGER antibody
    • IGHER antibody
    • LEU 16 antibody
    • LEU16 antibody
    • leukocyte surface antigen Leu 16 antibody
    • Leukocyte surface antigen Leu-16 antibody
    • Ly44 antibody
    • Membrane spanning 4 domains A1 antibody
    • Membrane spanning 4 domains subfamily A member 2 antibody
    • Membrane-spanning 4-domains subfamily A member 1 antibody
    • MS4A1 antibody
    • MS4A2 antibody
    • S7 antibody
    see all

Anti-CD20 antibody [2H7] (ab111274)参考文献

ab111274 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry free floating
Sample Human Tissue sections (Human B cells Lymphoma xenografted in rat tissue)
Specification Human B cells Lymphoma xenografted in rat tissue
Username

Mr. Fabien Fillesoye

Verified customer

提交于 Oct 21 2016

The 2H7 clone is not the same as the rituxan antibody and does not recognize the exact same epitope. I found an article that discusses in detail the differences between the two antibodies.

Crystal structure of chimeric antibody C2H7 Fab in com...

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Thank you for contacting us.

Unfortunately we have not performed any kind of cytotoxicity assays with these antibodies. I was however able to find a paper referring to these assays with a murine monoclonal antibody anti CD20 from clone [B-Ly1...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"