概述

  • 产品名称Anti-CD1a抗体[CD1a007]
    参阅全部 CD1a 一抗
  • 描述
    小鼠单克隆抗体[CD1a007] to CD1a
  • 特异性CD1a staining has been shown to be useful in the differentiation of Langerhans cells from interdigitating cells. It has also proved useful for phenotyping Langerhans cell histiocytosis.
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Prokaryotic recombinant fusion protein corresponding to the external portion of the CD1a molecule

  • 阳性对照
    • Skin or tonsil

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.30
    Preservative: 0.09% Sodium azide
    Constituent: Tissue culture supernatant
  • Concentration information loading...
  • 克隆单克隆
  • 克隆编号CD1a007
  • 骨髓瘤unknown
  • 同种型IgG1
  • 轻链类型unknown
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. For an ABC system, incubate for 30-60 minutes at RT.
IHC-Fr 1/25 - 1/50. For an ABC system, incubate for 30-60 minutes at RT.

靶标

  • 功能Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
  • 组织特异性Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
  • 序列相似性Contains 1 Ig-like (immunoglobulin-like) domain.
  • 细胞定位Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 1a antibody
    • CD1 antibody
    • CD1A antibody
    • CD1A Antigen antibody
    • CD1A antigen, a polypeptide antibody
    • CD1a molecule antibody
    • CD1A_HUMAN antibody
    • cluster of differentiation 1 A antibody
    • cortical thymocyte antigen CD1A antibody
    • differentiation antigen CD1 alpha 3 antibody
    • epidermal dendritic cell marker CD1a antibody
    • FCB 6 antibody
    • FCB6 antibody
    • HTA 1 antibody
    • HTA1 antibody
    • hTa1 thymocyte antigen antibody
    • OTTHUMP00000018907 antibody
    • R 4 antibody
    • R4 antibody
    • T 6 antibody
    • T-cell surface antigen T6/Leu-6 antibody
    • T-cell surface glycoprotein CD1a antibody
    • T6 antibody
    see all

Anti-CD1a antibody [CD1a007] 图像

  • Ab708 positively staining acetone fixed, frozen human skin sections (1/25).

    The secondary Ab used was biotin conjugated anti mouse (1/1) and formed part of of a commercially available kit (Vector labs RTU ABC kit).

    This image is courtesy of an Abreview submitted on 11 October 2005. We do not have any further information relating to this image.

Anti-CD1a antibody [CD1a007] (ab708)参考文献

This product has been referenced in:
  • Mazal PR  et al. Langerhans cell histiocytosis of the hypothalamus: diagnostic value of immunohistochemistry. Clin Neuropathol 15:87-91 (1996). Read more (PubMed: 8925602) »
  • Fivenson DP & Nickoloff BJ Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol 22:223-8 (1995). Read more (PubMed: 7593815) »

See all 3 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Skin)
Specification Skin
Fixative Formaldehyde
Antigen retrieval step Heat mediated
Blocking step Serum as blocking agent for 15 minute(s) · Concentration: 5%
Username

Dr. Julie Richards

Verified customer

提交于 Mar 05 2007

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (skin)
Specification skin
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 1 %
Username

Abcam user community

Verified customer

提交于 Oct 11 2005

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"