Anti-CD19抗体[MB19-1] (Biotin) (ab24956)

概述

  • 产品名称Anti-CD19抗体[MB19-1] (Biotin)
    参阅全部 CD19 一抗
  • 描述
    小鼠单克隆抗体[MB19-1] to CD19 (Biotin)
  • 偶联物Biotin
  • 特异性This antibody is specific to CD19 B cell differentiation antigen.
  • 经测试应用适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    The details of the immunogen for this antibody are not available.

性能

应用

Our Abpromise guarantee covers the use of ab24956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 106 cells.

ab37349 - Mouse monoclonal IgA, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.

靶标

  • 功能Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
  • 疾病相关Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Antibody deficiency due to defect in CD19, included antibody
    • AW495831 antibody
    • B lymphocyte antigen CD19 antibody
    • B lymphocyte surface antigen B4 antibody
    • B-lymphocyte antigen CD19 antibody
    • B-lymphocyte surface antigen B4 antibody
    • B4 antibody
    • CD19 antibody
    • CD19 antigen antibody
    • CD19 molecule antibody
    • Cd19 protein antibody
    • CD19_HUMAN antibody
    • CVID3 antibody
    • Differentiation antigen CD19 antibody
    • Leu 12 antibody
    • Leu-12 antibody
    • Leu12 antibody
    • MGC109570 antibody
    • MGC12802 antibody
    • T-cell surface antigen Leu-12 antibody
    see all

Anti-CD19 antibody [MB19-1] (Biotin) (ab24956)参考文献

ab24956 has not yet been referenced specifically in any publications.

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