Anti-CD19抗体[A3-B1] (Phycoerythrin) (ab91156)

概述

  • 产品名称Anti-CD19抗体[A3-B1] (Phycoerythrin)
    参阅全部 CD19 一抗
  • 描述
    小鼠单克隆抗体[A3-B1] to CD19 (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性This antibody is B lineage specific and reacts with early B cell precursors, pre pre B cells, pre B cells, B cells, intermediate B cells, mature B cells and some plasmacytoid cells. Plasma cells were found to be negative. The antibody does not react with other haemopoïetic cells. The antibody also reacts with pre B cell lines, B lymphoblastoid cell lines and Burkitt cell lines, and with 50% of myeloma cell lines. Virtually all non T ALL, B CLL and B cell lymphomas were found to be positive, myeloma cells were found to be negative.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation (Human)

性能

应用

Our Abpromise guarantee covers the use of ab91156 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: Use 20 µl/test

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    • 疾病相关Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻译后修饰Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Antibody deficiency due to defect in CD19, included antibody
      • AW495831 antibody
      • B lymphocyte antigen CD19 antibody
      • B lymphocyte surface antigen B4 antibody
      • B-lymphocyte antigen CD19 antibody
      • B-lymphocyte surface antigen B4 antibody
      • B4 antibody
      • CD19 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Cd19 protein antibody
      • CD19_HUMAN antibody
      • CVID3 antibody
      • Differentiation antigen CD19 antibody
      • Leu 12 antibody
      • Leu-12 antibody
      • Leu12 antibody
      • MGC109570 antibody
      • MGC12802 antibody
      • T-cell surface antigen Leu-12 antibody
      see all

    Anti-CD19 antibody [A3-B1] (Phycoerythrin) 图像

    • ab91156, at 20 µl/test, staining Human peripheral blood by Flow Cytometry.
    • ab91156, at 20 µl/test, staining Human lympbocytes by Flow Cytometry.

    Anti-CD19 antibody [A3-B1] (Phycoerythrin) (ab91156)参考文献

    ab91156 has not yet been referenced specifically in any publications.

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