Anti-CD19抗体[6D5] (PE/Cy5.5 ®) (ab25548)

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概述

  • 产品名称Anti-CD19抗体[6D5] (PE/Cy5.5 ®)
    参阅全部 CD19 一抗
  • 描述
    大鼠单克隆抗体[6D5] to CD19 (PE/Cy5.5 ®)
  • 偶联物PE/Cy5.5 ®. Ex: 496nm, Em: 690nm
  • 特异性CD19 B-cell differentiation antigen
  • 经测试应用适用于: Flow Cyt, IP, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse CD19-expressing K562 human erythroleukemia cells

  • 常规说明This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.

性能

应用

Our Abpromise guarantee covers the use of ab25548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IP
Functional Studies
  • 应用说明Flow Cyt: Use 0.2µg for 106 cells.
    IP: Use at an assay dependent dilution.
    In vivo and in vitro functional studies:Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • 靶标

    • 功能Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    • 疾病相关Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻译后修饰Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
      • 别名
        • Antibody deficiency due to defect in CD19, included antibody
        • AW495831 antibody
        • B lymphocyte antigen CD19 antibody
        • B lymphocyte surface antigen B4 antibody
        • B-lymphocyte antigen CD19 antibody
        • B-lymphocyte surface antigen B4 antibody
        • B4 antibody
        • CD19 antibody
        • CD19 antigen antibody
        • CD19 molecule antibody
        • Cd19 protein antibody
        • CD19_HUMAN antibody
        • CVID3 antibody
        • Differentiation antigen CD19 antibody
        • Leu 12 antibody
        • Leu-12 antibody
        • Leu12 antibody
        • MGC109570 antibody
        • MGC12802 antibody
        • T-cell surface antigen Leu-12 antibody
        see all

      Anti-CD19 antibody [6D5] (PE/Cy5.5 ®) (ab25548)参考文献

      This product has been referenced in:

      See all 3 Publications for this product

      发表研究结果有使用 ab25548？请让我们知道，以便我们可以引用本数据表中的参考文章。

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      Could you suggest antibody conjugated to Red dyes (PE)?

      Thank you for contacting us.

      Please check the following antibodies;


      http://www.abcam.com/cd19-antibody-6d5-pe-cy5-5-ab25548.html

      http://www.abcam.com/cd19-antibody-mb19-1-pe-cy5-5-ab25384.html

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"