Anti-CD19抗体[6D5] (Allophycocyanin) (ab25484)

概述

  • 产品名称Anti-CD19抗体[6D5] (Allophycocyanin)
    参阅全部 CD19 一抗
  • 描述
    大鼠单克隆抗体[6D5] to CD19 (Allophycocyanin)
  • 偶联物Allophycocyanin. Ex: 645nm, Em: 660nm
  • 特异性CD19 B-cell differentiation antigen
  • 经测试应用适用于: Flow Cyt, IP, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse CD19-expressing K562 human erythroleukemia cells

性能

应用

Our Abpromise guarantee covers the use of ab25484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IP
Functional Studies
  • 应用说明Flow Cyt: Use 0.2µg for 106 cells.
    IP: Use at an assay dependent dilution.
    In vivo and in vitro functional studies: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    • 疾病相关Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻译后修饰Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Antibody deficiency due to defect in CD19, included antibody
      • AW495831 antibody
      • B lymphocyte antigen CD19 antibody
      • B lymphocyte surface antigen B4 antibody
      • B-lymphocyte antigen CD19 antibody
      • B-lymphocyte surface antigen B4 antibody
      • B4 antibody
      • CD19 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Cd19 protein antibody
      • CD19_HUMAN antibody
      • CVID3 antibody
      • Differentiation antigen CD19 antibody
      • Leu 12 antibody
      • Leu-12 antibody
      • Leu12 antibody
      • MGC109570 antibody
      • MGC12802 antibody
      • T-cell surface antigen Leu-12 antibody
      see all

    Anti-CD19 antibody [6D5] (Allophycocyanin) (ab25484)参考文献

    This product has been referenced in:

    See all 3 Publications for this product

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Flow Cytometry
    Sample Mouse Cell (splenocytes)
    Specification splenocytes
    Preparation Cell harvesting/tissue preparation method: cell suspension
    Sample buffer: PBS
    Permeabilization No
    Gating Strategy Live cells
    Username

    Abcam user community

    Verified customer

    提交于 May 25 2010

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Flow Cytometry
    Sample Mouse Cell (fetal liver)
    Specification fetal liver
    Preparation Cell harvesting/tissue preparation method: Cells were isolated and a cell suspension prepared
    Sample buffer: PBS
    Permeabilization No
    Gating Strategy live cells
    Username

    Abcam user community

    Verified customer

    提交于 Jun 05 2008

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"