概述

  • 产品名称
    Anti-CD19抗体[1D3] (Phycoerythrin)
    参阅全部 CD19 一抗
  • 描述
    大鼠单克隆抗体[1D3] to CD19 (Phycoerythrin)
  • 偶联物
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse CD19-transfected cell line

性能

应用

Our Abpromise guarantee covers the use of ab90753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.

ab134674-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能
    Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
  • 疾病相关
    Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰
    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Antibody deficiency due to defect in CD19, included antibody
    • AW495831 antibody
    • B lymphocyte antigen CD19 antibody
    • B lymphocyte surface antigen B4 antibody
    • B-lymphocyte antigen CD19 antibody
    • B-lymphocyte surface antigen B4 antibody
    • B4 antibody
    • CD19 antibody
    • CD19 antigen antibody
    • CD19 molecule antibody
    • Cd19 protein antibody
    • CD19_HUMAN antibody
    • CVID3 antibody
    • Differentiation antigen CD19 antibody
    • Leu 12 antibody
    • Leu-12 antibody
    • Leu12 antibody
    • MGC109570 antibody
    • MGC12802 antibody
    • T-cell surface antigen Leu-12 antibody
    see all

图片

  • Flow Cytometry analysis of C57Bl/6 splenocytes labeling CD19 with ab90753 at 0.125µg (solid line). Rat IgG2a (Phycoerythrin)isotype control at 0.125µg (dotted line).

文献

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