Anti-CD161抗体[PK136] (ab22515)

概述

  • 产品名称
    Anti-CD161抗体[PK136]
    参阅全部 CD161 一抗
  • 描述
    小鼠单克隆抗体[PK136] to CD161
  • 经测试应用
    适用于: Flow Cyt, IP, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
    不与反应: Rat, Human
  • 免疫原

    Tissue/ cell preparation (Mouse): Spleen and bone marrow cells from CE mice

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C. Do Not Freeze.
  • 存储溶液
    pH: 7.2
    Preservative: 0.09% Sodium azide
    Constituents: 0.88% Sodium chloride, 0.12% Monobasic dihydrogen sodium phosphate
  • Concentration information loading...
  • 纯度
    Affinity purified
  • 克隆
    单克隆
  • 克隆编号
    PK136
  • 骨髓瘤
    Sp2/0-Ag14
  • 同种型
    IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab22515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.
Functional Studies Use a concentration of 1 - 10 µg/ml.

靶标

  • 功能
    Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
  • 组织特异性
    Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
  • 序列相似性
    Contains 1 C-type lectin domain.
  • 翻译后修饰
    N-glycosylated. Contains sialic acid residues.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-type lectin domain family 5 member B antibody
    • CD161 antibody
    • CLEC5B antibody
    • HNKR-P1a antibody
    • Killer Cell Lectin like Receptor Subfamily B Member 1 antibody
    • Killer cell lectin-like receptor subfamily B member 1 antibody
    • KLRB1 antibody
    • KLRB1_HUMAN antibody
    • Natural killer cell surface protein P1A antibody
    • NKR antibody
    • NKR P1 antibody
    • NKR-P1A antibody
    • NKRP1 antibody
    • NKRP1A antibody
    see all

文献

ab22515 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for your enquiry. I have been in touch with the source of this antibody and I can tell you that whilst batches are routinely tested by flow cytometry the application of in vivo depletion was added as a result of the clone being shown to ex...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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