Anti-CD161抗体[10/78] (Biotin) (ab33969)

概述

  • 产品名称Anti-CD161抗体[10/78] (Biotin)
    参阅全部 CD161 一抗
  • 描述
    小鼠单克隆抗体[10/78] to CD161 (Biotin)
  • 偶联物Biotin
  • 特异性ab33969 recognises the rat CD161 protein (also known as NKRPI)
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Tissue/ cell preparation (Rat) Purified splenic NK cells from the LEW rat strain.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Prepared from tissue culture supernatant.
  • 克隆单克隆
  • 克隆编号10/78
  • 骨髓瘤x63-Ag8.653
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab33969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: Use neat, or 10µl of the suggested working dilution to label 106 cells in 100µl.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
    • 组织特异性Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
    • 序列相似性Contains 1 C-type lectin domain.
    • 翻译后修饰N-glycosylated. Contains sialic acid residues.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C-type lectin domain family 5 member B antibody
      • CD161 antibody
      • CLEC5B antibody
      • HNKR-P1a antibody
      • Killer Cell Lectin like Receptor Subfamily B Member 1 antibody
      • Killer cell lectin-like receptor subfamily B member 1 antibody
      • KLRB1 antibody
      • KLRB1_HUMAN antibody
      • Natural killer cell surface protein P1A antibody
      • NKR antibody
      • NKR P1 antibody
      • NKR-P1A antibody
      • NKRP1 antibody
      • NKRP1A antibody
      see all

    Anti-CD161 antibody [10/78] (Biotin) (ab33969)参考文献

    ab33969 has not yet been referenced specifically in any publications.

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