The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-CD14 antibody (ab45870)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Monocyte differentiation antigen CD14
Monocyte differentiation antigen CD14 urinary form
Monocyte differentiation antigen CD14, membrane-bound form
Myeloid cell specific leucine rich glycoprotein
Myeloid cell-specific leucine-rich glycoprotein
功能Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
组织特异性Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
序列相似性Contains 11 LRR (leucine-rich) repeats.
翻译后修饰N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.