Anti-CD14抗体[UCHM1] (ab6623)

概述

  • 产品名称
    Anti-CD14抗体[UCHM1]
    参阅全部 CD14 一抗
  • 描述
    小鼠单克隆抗体[UCHM1] to CD14
  • 特异性
    ab6623 recognises a monocyte surface antigen of 55 kDa found chiefly on monocytes. UCHM1 was clustered at the Third International Workshop and Conference on Human Leucocyte Differentiation Antigens. Oxford 1986, as CDw14, group A. In tonsil tissue sections UCHM1 gives positive staining reactions with monocytic cells, the interfollicular tissue macrophages seen under the capsule, and dendritic reticulum cells. Skin Langerhans cells are always negative. UCHM1 also reacts with Kupffer cells and sinus lining cells on the liver.
  • 经测试应用
    适用于: Flow Cyt, IHC-Frmore details
    不适用于: IHC-P
  • 种属反应性
    与反应: Human, Cynomolgus monkey, Rhesus monkey
  • 免疫原

    Human Thymocytes followed by peripheral blood mononuclear cells

  • 阳性对照
    • Tonsil.

性能

应用

Our Abpromise guarantee covers the use of ab6623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.
IHC-Fr 1/10.
  • 应用说明
    Is unsuitable for IHC-P.
  • 靶标

    • 功能
      Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
    • 组织特异性
      Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
    • 序列相似性
      Contains 11 LRR (leucine-rich) repeats.
    • 翻译后修饰
      N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
    • 细胞定位
      Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 14 antibody
      • CD_antigen=CD14 antibody
      • CD14 antibody
      • CD14 antigen antibody
      • CD14 molecule antibody
      • CD14_HUMAN antibody
      • LPS-R antibody
      • Mo2 antibody
      • Monocyte differentiation antigen CD14 antibody
      • Monocyte differentiation antigen CD14 urinary form antibody
      • Monocyte differentiation antigen CD14, membrane-bound form antibody
      • Myeloid cell specific leucine rich glycoprotein antibody
      • Myeloid cell-specific leucine-rich glycoprotein antibody
      see all

    图片

    • ab6623 staining of human peripheral blood monocytes, visualised with rabbit anti-mouse IgG: FITC.

    文献

    ab6623 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    This antibody has been tested on paraffin sections and does not work. In IHC, it is known to work only with frozen sections.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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