The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 40 kDa.
Use under reducing conditions.
Use at an assay dependent concentration.
1/50 - 1/200.
Use 5µl of the suggested working dilution to label 106 cells or 100µl whole blood.
ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
功能Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
组织特异性Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
序列相似性Contains 11 LRR (leucine-rich) repeats.
翻译后修饰N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.